RESUMEN
OBJECTIVE: The COVID-19 vaccination has been linked to numerous reports of menstrual disorders as potential side effects. However, menstrual cycle results after vaccination were not collected throughout clinical trials. According to other research, COVID-19 vaccination and menstrual disorders have no discernible connection, and menstrual disorders are temporary. SUBJECTS AND METHODS: We asked questions about menstruation disturbances following the first and second doses of the COVID-19 vaccine in a population-based cohort of adult Saudi women to determine whether the vaccination is linked to menstrual cycle irregularities. RESULTS: According to the results, 63.9% of women experienced variations in their menstrual cycle either after the first or second dose. Such results show that COVID-19 vaccination impacts women's menstrual cycles. However, there is no need for concern because the alterations are relatively minor, and the menstrual cycle usually returns to normal within two months. Additionally, there are no obvious distinctions between the various vaccine types or body mass. CONCLUSIONS: Our findings support and explain the self-reports of menstrual cycle variations. We have discussed reasons for these problems that describe the mechanism of the relationship between them and the immune response. Such reasons will help prevent hormonal imbalances and the influence of therapies and immunizations on the reproductive system.